Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | CPA1 | P15085 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085763 | 0.88 | ITGB1 (0.56) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL2252892 | 0.88 | FOLH1 (0.56) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL2252894 | 0.88 | FOLH1 (0.56) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL5086266 | 0.88 | ITGB1 (0.56) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL844471 | 0.88 | ITGB3 (0.58) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL2185240 | 0.88 | ITGB3 (0.58) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL7758997 | 0.88 | ITGB3 (0.58) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL16680705 | 0.88 | ITGB3 (0.48) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL8197676 | 0.87 | ITGB3 (0.49) | ACEMMECPA1ACE2ITGB3 | |
| SCHEMBL8023605 | 0.87 | ITGB1 (0.52) | ITGB3ITGA2BITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234982-A1 | SUBSTITUTED HYDANTOINS AS MEK KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080523-A1 | SUBSTITUTED HYDANTOINS AS MEK KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| EP-1791837-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029862-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |