Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FABP7 | O15540 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28775658 | 1.00 | EPHX1 (0.43) | EPHX1CES2CES1CA1CA2 | |
| Bicarbonate SCHEMBL6566447 | 1.00 | EPHX1 (0.43) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL909903 | 0.87 | EPHX1 (0.39) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL36848 | 0.84 | CA1 (0.41) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL28573115 | 0.84 | CA1 (0.41) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL11679637 | 0.84 | CA1 (0.41) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL11638037 | 0.84 | CA1 (0.41) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL6507671 | 0.81 | EPHX1 (0.39) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL7015517 | 0.81 | EPHX1 (0.43) | EPHX1CES2CES1CA1CA2 | |
| SCHEMBL15157468 | 0.81 | CA1 (0.39) | EPHX1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109762117-A | The synthetic method of polyether polyol | 山东蓝星东大有限公司 | 2019-05-17 | — | — | CN | claimed |
| CN-108634477-A | A kind of manufacturing method of internal height-increasing shoe | 广州市鸿峥实业有限公司 | 2018-10-12 | — | — | CN | claimed |
| EP-3652245-B1 | ADDITIVE MIXTURES FOR PLASTICS, LASER-MARKABLE POLYMER COMPOSITIONS CONTAINING SAME, AND USE THEREOF | CLARIANT INT LTD (CH) | 2024-04-24 | — | — | EP | disclosed |
| US-11945913-B2 | Thermosetting polyimide resin and manufacturing method thereof, composition, prepolymer, film, adhesive, and use thereof | CHIN YEE CHEMICAL INDUSTRIES CO., LTD. (TW) | 2024-04-02 | — | — | US | disclosed |
| EP-3652241-B1 | ADDITIVE MIXTURES FOR PLASTICS, LASER-MARKABLE POLYMER COMPOSITIONS CONTAINING SAME AND USE THEREOF | CLARIANT INT LTD (CH) | 2023-04-19 | — | — | EP | disclosed |
| CN-115894804-A | Copolymer containing PVDF unit, preparation method thereof, humidity-sensitive film and application of humidity-sensitive film | 广州奥松电子股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115286767-A | Antibacterial fluorine modified epoxy vinyl ester resin, preparation method thereof and multi-mechanism synergetic universal anticorrosive coating | 海洋化工研究院有限公司 | 2022-11-04 | — | — | CN | disclosed |
| WO-2020186482-A1 | POLYMER AND PREPARATION METHOD AND APPLICATION THEREOF | 深圳大学 | 2020-09-24 | — | — | WO | disclosed |
| CN-107556433-B | Dynamic polymer elastomer with hybrid cross-linked network and application thereof | 翁秋梅 | 2020-07-31 | — | — | CN | disclosed |
| EP-3679094-A1 | FLAME RETARDANT COMBINATIONS FOR POLYMER COMPOSITIONS AND USE THEREOF | Clariant Plastics & Coatings Ltd (CH) | 2020-07-15 | — | — | EP | disclosed |
| EP-3679095-A1 | SYNERGISTIC FLAME RETARDANT COMBINATIONS FOR POLYMER COMPOSITIONS AND USE THEREOF | Clariant Plastics & Coatings Ltd (CH) | 2020-07-15 | — | — | EP | disclosed |
| EP-0815839-A2 | Cosmetic or pharmaceutical composition containing an acrylic polymer | BASF AKTIENGESELLSCHAFT (DE) | 1998-01-07 | — | — | EP | disclosed |
| EP-0780401-A1 | Process for preparing polymers by emulsion polymerization | BASF AKTIENGESELLSCHAFT (DE) | 1997-06-25 | — | — | EP | disclosed |
| EP-0666878-B1 | NEW POLYMERS BASED ON POLYARYLENE SILOXANES AND RADICALLY POLYMERISABLE MONOMERS | HOECHST AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0666878-A1 | NEW POLYMERS BASED ON POLYARYLENE SILOXANES AND RADICALLY POLYMERISABLE MONOMERS. | HOECHST AG (DE) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010218-A1 | NEW POLYMERS BASED ON POLYARYLENE SILOXANES AND RADICALLY POLYMERISABLE MONOMERS | HOESCHT AKTIENGESELLSCHAFT (DE) | 1994-05-11 | — | — | WO | disclosed |
| EP-0332670-A1 | COLOURLESS TRANSPARENT POLYMER MATERIAL | Carl-Zeiss-Stiftung trading as SCHOTT GLASWERKE (DE) | 1989-09-20 | — | — | EP | disclosed |
| WO-1989001952-A1 | COLOURLESS TRANSPARENT POLYMER MATERIAL | SCHOTT GLASWERKE (DE) | 1989-03-09 | — | — | WO | disclosed |
| US-4715999-A | Process of making optical blanks | SCHOTT GLASWERKE (DE) | 1987-12-29 | — | — | US | disclosed |
| EP-0106991-B1 | PROCESS FOR PREPARING COPOLYMERS OF MONOETHYLENICALLY UNSATURATED MONO- AND DICARBOXYLIC ACIDS (ANHYDRIDE) | BASF Aktiengesellschaft (DE) | 1987-05-13 | — | — | EP | disclosed |