Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650526 | 0.89 | LPL (0.42) | LPLLIPGFFAR1PRKAA2TP53 | |
| SCHEMBL648886 | 0.88 | CHRM4 (0.40) | LPLLIPGFFAR1PRKAA2TP53 | |
| SCHEMBL648885 | 0.85 | FFAR1 (0.40) | LPLLIPGFFAR1PRKAA2TP53 | |
| SCHEMBL3668147 | 0.81 | PRKAA2 (0.49) | LPLLIPGFFAR1PRKAA2 | |
| SCHEMBL2505772 | 0.80 | SLC6A5 (0.60) | PRKAA2CHRM2DRD4 | |
| SCHEMBL651008 | 0.80 | SCN9A (0.51) | LPLLIPGPRKAA2DEGS1CSF1R | |
| SCHEMBL651111 | 0.80 | SCN9A (0.51) | LPLLIPGPRKAA2DEGS1CSF1R | |
| SCHEMBL651007 | 0.80 | SCN9A (0.51) | LPLLIPGPRKAA2DEGS1CSF1R | |
| SCHEMBL649469 | 0.79 | PRKAA2 (0.47) | LPLLIPGPRKAA2DRD2DRD4 | |
| SCHEMBL648104 | 0.79 | SLC6A5 (0.53) | PRKAA2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |