Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 9/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664145 | 1.00 | HCRTR2 (0.38) | HCRTR2HCRTR1HSD11B1LMNATSHR | |
| SCHEMBL3665247 | 0.89 | GPBAR1 (0.43) | HCRTR2HCRTR1HSD11B1LMNATSHR | |
| SCHEMBL3660112 | 0.89 | GPBAR1 (0.43) | HCRTR2HCRTR1HSD11B1LMNATSHR | |
| SCHEMBL3665517 | 0.89 | HCRTR2 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL3663234 | 0.89 | HCRTR2 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL3665837 | 0.84 | HCRTR2 (0.39) | HCRTR2HCRTR1LMNATSHR | |
| SCHEMBL3663295 | 0.82 | HCRTR1 (0.39) | HCRTR2HCRTR1HSD11B1LMNATSHR | |
| SCHEMBL3663775 | 0.82 | HCRTR1 (0.39) | HCRTR2HCRTR1HSD11B1LMNATSHR | |
| SCHEMBL3663236 | 0.80 | SCD5 (0.40) | HCRTR2HCRTR1 | |
| SCHEMBL3664032 | 0.79 | LMNA (0.42) | HCRTR2HSD11B1LMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231650-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Biovitrum AB (publ) (SE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009090239-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (PUBL) (SE) | 2009-07-23 | — | — | WO | disclosed |