Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933822 | 0.86 | FBP1 (0.49) | MAPTFBP1PTGES2KMT2AALDH1A1 | |
| SCHEMBL194745 | 0.84 | MAPT (0.53) | MAPTFBP1PTGES2KMT2AALDH1A1 | |
| SCHEMBL682128 | 0.82 | MAPT (0.63) | MAPTFBP1KMT2AALDH1A1HTT | |
| SCHEMBL3933827 | 0.81 | FBP1 (0.48) | MAPTFBP1PTGES2KMT2AALDH1A1 | |
| SCHEMBL19341771 | 0.78 | MAPT (0.51) | MAPTFBP1KMT2AALDH1A1HTT | |
| SCHEMBL8230214 | 0.77 | KMT2A (0.53) | MAPTFBP1PTGES2KMT2AALDH1A1 | |
| SCHEMBL4207122 | 0.77 | KMT2A (0.53) | MAPTPTGES2KMT2AALDH1A1HTT | |
| SCHEMBL6804437 | 0.77 | HTR6 (0.55) | MAPTFBP1PTGES2KMT2AALDH1A1 | |
| SCHEMBL24254279 | 0.77 | KMT2A (0.56) | MAPTPTGES2KMT2AALDH1A1HTT | |
| SCHEMBL265540 | 0.76 | FBP1 (0.52) | MAPTFBP1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101300013-B | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto | PORTOLA PHARM INC | 2012-11-28 | — | — | CN | disclosed |
| EP-2146705-A2 | COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR | Portola Pharmaceuticals, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008137787-A2 | COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| CN-101300013-A | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto | PORTOLA PHARM INC (US) | 2008-11-05 | — | — | CN | disclosed |
| EP-1412364-A1 | PLATELET ADP RECEPTOR INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011872-A1 | PLATELET ADP RECEPTOR INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |