Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655180 | 0.78 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3768894 | 0.78 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3768901 | 0.78 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3663740 | 0.74 | ALDH1A1 (0.38) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1464059 | 0.73 | RIPK1 (0.43) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1464039 | 0.68 | IGF1R (0.36) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3661629 | 0.65 | NPC1 (0.44) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3661631 | 0.65 | NPC1 (0.44) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3207998 | 0.63 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3207967 | 0.63 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220052-B1 | CYCLIC UREA INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2015-03-25 | — | — | EP | disclosed |
| EP-2220052-A1 | CYCLIC UREA INHIBITORS OF 11 -HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009061498-A1 | CYCLIC UREA INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |