SCHEMBL3663751

SCHEMBL3663751

CN(C)c1cccc2c(S(=O)(=O)NCCCCCC(=O)NO)cccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 1.00
HDAC4 P56524 2/20 1.00
HDAC10 Q969S8 2/20 1.00
HDAC5 Q9UQL6 2/20 1.00
GBA1 P04062 3/20 0.65
HDAC3 O15379 2/20 0.61
HDAC1 Q13547 2/20 0.61
HDAC2 Q92769 2/20 0.61
HDAC7 Q8WUI4 1/20 0.61
HDAC11 Q96DB2 1/20 0.61
HDAC8 Q9BY41 1/20 0.61
GLB1 P16278 4/20 0.58
NCOR2 Q9Y618 1/20 0.58
FUCA1 P04066 1/20 0.56
EPHX2 P34913 1/20 0.53
PTGS2 P35354 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7999790 1.00 HDAC6 (1.00) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL8021912 1.00 HDAC6 (1.00) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL8018886 0.99 HDAC6 (0.98) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL15515613 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL15507473 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL8016351 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL591663 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL15515796 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL18257191 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1
SCHEMBL15259321 0.88 HDAC4 (0.79) HDAC6HDAC4HDAC10HDAC5GBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8293513-B2 Histone deacetylase inhibitors GEORGETOWN UNIVERSITY (US) 2012-10-23 US claimed
CN-101970399-A Histone deacetylase inhibitors UNIV GEORGETOWN 2011-02-09 CN claimed
US-20100317739-A1 HISTONE DEACETYLASE INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-12-16 US claimed
EP-2231596-A1 HISTONE DEACETYLASE INHIBITORS Georgetown University (US) 2010-09-29 EP claimed
WO-2009079375-A1 HISTONE DEACETYLASE INHIBITORS GEORGETOWN UNIVERSITY (US) 2009-06-25 WO claimed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-08-05 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed
US-8293513-B2 Histone deacetylase inhibitors GEORGETOWN UNIVERSITY (US) 2012-10-23 US disclosed
CN-101970399-A Histone deacetylase inhibitors UNIV GEORGETOWN 2011-02-09 CN disclosed
US-20100317739-A1 HISTONE DEACETYLASE INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-12-16 US disclosed
EP-2231596-A1 HISTONE DEACETYLASE INHIBITORS Georgetown University (US) 2010-09-29 EP disclosed
WO-2009079375-A1 HISTONE DEACETYLASE INHIBITORS GEORGETOWN UNIVERSITY (US) 2009-06-25 WO disclosed
WO-2009079375-A1 HISTONE DEACETYLASE INHIBITORS GEORGETOWN UNIVERSITY (US) 2009-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ATXN2L, ATXN2, ATXN10 HDAC6 898/4885HDAC4 2320/4885HDAC10 1110/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 HDAC6 1477/4885HDAC4 2054/4885HDAC10 783/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 HDAC6 1477/4885HDAC4 2054/4885HDAC10 783/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 HDAC6 716/4885HDAC4 2401/4885HDAC10 834/4885
US-20100317739-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC5, HDAC2 HDAC6 10/4885HDAC4 8/4885HDAC10 11/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN HDAC6 645/4885HDAC4 785/4885HDAC10 408/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF HDAC6 357/4885HDAC4 1375/4885HDAC10 312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.