Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663820 | 0.90 | PRKAA2 (0.51) | PRKAA2EPHX2 | |
| SCHEMBL649469 | 0.86 | PRKAA2 (0.47) | LPLLIPGPRKAA2ADRB2SLC6A5 | |
| SCHEMBL649758 | 0.84 | PRKAA2 (0.49) | PRKAA2ADRB2SLC6A5TEAD1 | |
| SCHEMBL650342 | 0.84 | PRKAA2 (0.49) | PRKAA2ADRB2SLC6A5TEAD1 | |
| SCHEMBL649757 | 0.84 | PRKAA2 (0.49) | PRKAA2ADRB2SLC6A5TEAD1 | |
| SCHEMBL648104 | 0.84 | SLC6A5 (0.53) | PRKAA2ADRB2SLC6A5TEAD1 | |
| SCHEMBL3798034 | 0.80 | SLC6A5 (0.50) | LPLLIPGPRKAA2FFAR1SLC6A5 | |
| SCHEMBL648886 | 0.78 | CHRM4 (0.40) | LPLLIPGPRKAA2F10FFAR1 | |
| SCHEMBL648570 | 0.78 | SLC6A5 (0.52) | PRKAA2ADRB2SLC6A5TEAD1 | |
| SCHEMBL647670 | 0.78 | SLC6A5 (0.64) | PRKAA2SLC6A5HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |