Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799739 | 0.89 | PRKAA2 (0.51) | PRKAA2PRKAB2CYP3A4PRKAG1PRKAA1 | |
| SCHEMBL647670 | 0.89 | SLC6A5 (0.64) | SLC6A5HIF1AEPAS1KCNH2MCHR1 | |
| SCHEMBL3801004 | 0.88 | PRKAA2 (0.53) | PRKAA2PRKAB2CYP3A4PRKAG1PRKAA1 | |
| SCHEMBL3665414 | 0.88 | SLC6A5 (0.50) | SLC6A5HIF1AEPAS1FFAR1KCNH2 | |
| SCHEMBL3662664 | 0.86 | SLC6A5 (0.46) | SLC6A5HIF1AEPAS1FFAR1KCNH2 | |
| SCHEMBL3668577 | 0.85 | SLC6A5 (0.45) | SLC6A5HIF1AEPAS1FFAR1KCNH2 | |
| SCHEMBL3660163 | 0.84 | F10 (0.39) | SLC6A5KCNH2PRKAA2LPLLIPG | |
| SCHEMBL3662737 | 0.83 | MDM2 (0.41) | SLC6A5PRKAA2 | |
| SCHEMBL3666697 | 0.82 | PRKAA2 (0.43) | SLC6A5FFAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL648104 | 0.81 | SLC6A5 (0.53) | SLC6A5PRKAA2PRKAB2CYP3A4PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |