Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3859730 | 0.91 | AKR1C3 (0.54) | RAB9ANPC1AKR1C3AKR1C1FFAR1 | |
| SCHEMBL29428983 | 0.83 | NOTUM (0.41) | AKR1C3AKR1C1KDM1ALTA4HMEN1 | |
| SCHEMBL12477256 | 0.83 | AKR1C3 (0.39) | RAB9ANPC1AKR1C3AKR1C1KDM1A | |
| SCHEMBL2077447 | 0.79 | GAA (0.45) | RAB9ANPC1KDM1AMAOBMEN1 | |
| SCHEMBL9940281 | 0.78 | TSHR (0.41) | AKR1C3AKR1C1KDM1ALTA4HKMT2A | |
| SCHEMBL29705664 | 0.77 | FFAR1 (0.47) | RAB9ANPC1KDM1AMAOBFFAR1 | |
| SCHEMBL4618863 | 0.75 | KDM1A (0.43) | AKR1C3AKR1C1KDM1AFFAR1HPGD | |
| SCHEMBL29428973 | 0.75 | AKR1C3 (0.42) | NPC1AKR1C3AKR1C1CYP1A2CYP2C9 | |
| SCHEMBL29428980 | 0.75 | AKR1C3 (0.41) | AKR1C3AKR1C1KDM1AMEN1KMT2A | |
| Biphenyl SCHEMBL7614586 | 0.74 | RAB9A (0.63) | RAB9ANPC1AKR1C3AKR1C1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142505-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer, Inc. (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008120093-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 2008-10-09 | — | — | WO | disclosed |