Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3859730 | 0.87 | AKR1C3 (0.54) | TSHRPARP1AKR1C3AKR1C1USP30 | |
| SCHEMBL3664867 | 0.78 | RAB9A (0.54) | AKR1C3AKR1C1SMN1; SMN2KDM1AKMT2A | |
| SCHEMBL31624021 | 0.76 | KDM1A (0.45) | TSHRSMN1; SMN2KDM1ACYP2C19 | |
| SCHEMBL31624181 | 0.75 | BACE1 (0.37) | ALDH1A1 | |
| SCHEMBL1195857 | 0.74 | TSHR (0.64) | TSHRKDM4ESMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL1265899 | 0.74 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL1265897 | 0.74 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL12926851 | 0.74 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL1265907 | 0.74 | TSHR (0.48) | TSHRAKR1C3AKR1C1SMN1; SMN2SLC6A2 | |
| SCHEMBL1265905 | 0.74 | TSHR (0.48) | TSHRAKR1C3AKR1C1SMN1; SMN2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020162471-A1 | PYRIDONE DERIVATIVE | マルホ株式会社 | 2020-08-13 | — | — | WO | disclosed |
| EP-2651930-A1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | Boehringer Ingelheim International GmbH (DE) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082817-A1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |