Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663269 | 1.00 | TRPV1 (0.36) | TRPV1HCRTR1HCRTR2CNR2PTGES | |
| SCHEMBL3661558 | 0.91 | HCRTR2 (0.39) | HCRTR1HCRTR2GRM5SMN1; SMN2LMNA | |
| SCHEMBL3665234 | 0.91 | HCRTR2 (0.39) | HCRTR1HCRTR2GRM5SMN1; SMN2LMNA | |
| SCHEMBL3658400 | 0.90 | GRM5 (0.42) | TRPV1HCRTR1HCRTR2GRM5NPC1 | |
| SCHEMBL3656862 | 0.90 | GRM5 (0.42) | TRPV1HCRTR1HCRTR2GRM5NPC1 | |
| SCHEMBL3665835 | 0.89 | GRM5 (0.45) | HCRTR1HCRTR2GRM5 | |
| SCHEMBL3666816 | 0.86 | HCRTR2 (0.41) | HCRTR1HCRTR2GRM5HSD11B1 | |
| SCHEMBL3664407 | 0.86 | HCRTR2 (0.41) | HCRTR1HCRTR2GRM5HSD11B1 | |
| SCHEMBL3665268 | 0.84 | HCRTR1 (0.39) | HCRTR1HCRTR2NPC1RAB9AHSD11B1 | |
| SCHEMBL3664194 | 0.84 | HCRTR1 (0.39) | HCRTR1HCRTR2NPC1RAB9AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231650-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Biovitrum AB (publ) (SE) | 2010-09-29 | — | — | EP | claimed |
| WO-2009090239-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (PUBL) (SE) | 2009-07-23 | — | — | WO | claimed |
| EP-2231650-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Biovitrum AB (publ) (SE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009090239-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (PUBL) (SE) | 2009-07-23 | — | — | WO | disclosed |