Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665267 | 0.89 | TRPV1 (0.36) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3663269 | 0.89 | TRPV1 (0.36) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3664407 | 0.85 | HCRTR2 (0.41) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3666816 | 0.85 | HCRTR2 (0.41) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3665234 | 0.84 | HCRTR2 (0.39) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3661558 | 0.84 | HCRTR2 (0.39) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3664194 | 0.83 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL3665268 | 0.83 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL3656862 | 0.83 | GRM5 (0.42) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL3658400 | 0.83 | GRM5 (0.42) | GRM5HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231650-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Biovitrum AB (publ) (SE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009090239-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (PUBL) (SE) | 2009-07-23 | — | — | WO | disclosed |