Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675868 | 1.00 | HTR6 (0.42) | HTR6TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL16241826 | 1.00 | HTR6 (0.42) | HTR6TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL679195 | 0.91 | SRC (0.40) | HTR6TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL675484 | 0.91 | SRC (0.40) | HTR6TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL674230 | 0.87 | HTR6 (0.44) | HTR6TP53MAPTPOLBL3MBTL1 | |
| SCHEMBL675451 | 0.84 | NFE2L2 (0.40) | HTR6TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL675278 | 0.84 | SRC (0.41) | HTR6TP53L3MBTL1 | |
| SCHEMBL676360 | 0.83 | HDAC3 (0.44) | HTR6TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL16241827 | 0.83 | HTR6 (0.41) | HTR6TP53MAPTHDAC3HDAC4 | |
| SCHEMBL675268 | 0.83 | HDAC3 (0.41) | HTR6TP53MAPTSMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | claimed |