Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 2/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123078 | 0.89 | RAD51 (0.50) | RAD51TRPV4DDR1CYP2A6 | |
| SCHEMBL124134 | 0.85 | RAD51 (0.47) | RAD51TRPV4CYP2C19 | |
| SCHEMBL122510 | 0.80 | RAD51 (0.53) | RAD51TRPV4 | |
| SCHEMBL11615934 | 0.76 | RAD51 (0.53) | RAD51TRPV4DYRK1A | |
| SCHEMBL20488808 | 0.76 | TRPV4 (0.48) | TRPV4PTGDR2DDR1CYP3A4 | |
| SCHEMBL123288 | 0.76 | RAD51 (0.49) | RAD51TRPV4TBXA2R | |
| SCHEMBL7387829 | 0.73 | RAD51 (0.49) | RAD51TRPV4 | |
| SCHEMBL30607191 | 0.73 | MEN1 (0.43) | MEN1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL1859259 | 0.73 | CYP2A6 (0.44) | RAD51TRPV4CYP2A6MEN1KMT2A | |
| SCHEMBL29952696 | 0.73 | CYP2A6 (0.44) | RAD51TRPV4CYP2A6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234985-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080199-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |