Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 7/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATF4 | P18848 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663733 | 0.93 | SLC6A4 (0.43) | MCHR1HRH3HTR1ADRD2HTR2A | |
| SCHEMBL648725 | 0.86 | CHRM4 (0.60) | CHRM4MCHR1CHRM2 | |
| Trifluoroacetic Acid SCHEMBL650115 | 0.84 | CHRM4 (0.58) | CHRM4MCHR1CHRM2 | |
| SCHEMBL3668600 | 0.82 | DRD4 (0.52) | MCHR1 | |
| SCHEMBL3670654 | 0.81 | CHRM4 (0.44) | CHRM4MCHR1CHRM2EPHX2 | |
| SCHEMBL647420 | 0.80 | CHRM4 (0.51) | CHRM4MCHR1CHRM2 | |
| SCHEMBL3663685 | 0.80 | HRH3 (0.52) | HRH3EPHX2 | |
| Trifluoroacetic Acid SCHEMBL649900 | 0.80 | CHRM4 (0.50) | CHRM4MCHR1CHRM2 | |
| SCHEMBL3663596 | 0.79 | PRKAA2 (0.49) | MCHR1HRH3 | |
| SCHEMBL649755 | 0.79 | SLC6A5 (0.54) | CHRM4MCHR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |