Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.45 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649756 | 0.91 | DRD4 (0.59) | DRD4SIGMAR1MCHR1ACHEUBE2M | |
| SCHEMBL3663733 | 0.86 | SLC6A4 (0.43) | DRD4FFAR1MCHR1ACHESLC6A5 | |
| SCHEMBL3663596 | 0.85 | PRKAA2 (0.49) | MCHR1ACHEKDM4EALDH1A1HPGD | |
| SCHEMBL649755 | 0.82 | SLC6A5 (0.54) | DRD4SIGMAR1MCHR1ACHEKDM4E | |
| SCHEMBL3665644 | 0.82 | CHRM4 (0.43) | MCHR1 | |
| SCHEMBL4430440 | 0.80 | DRD4 (0.59) | DRD4SIGMAR1MCHR1UBE2MDCUN1D1 | |
| SCHEMBL649902 | 0.79 | SIGMAR1 (0.56) | SIGMAR1MCHR1ACHEKDM4EALDH1A1 | |
| SCHEMBL647657 | 0.79 | ACHE (0.59) | DRD4SIGMAR1MCHR1ACHEKDM4E | |
| SCHEMBL648322 | 0.78 | DRD4 (0.52) | DRD4SIGMAR1MCHR1ACHEKDM4E | |
| SCHEMBL648725 | 0.78 | CHRM4 (0.60) | MCHR1ACHEKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |