Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.39 |
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | STAT5B | P51692 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | STAT5A | P42229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024002 | 1.00 | JAK2 (0.39) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3009495 | 0.84 | JAK3 (0.42) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3671586 | 0.84 | JAK3 (0.42) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL2562058 | 0.81 | NTRK1 (0.47) | JAK2JAK3NTRK1CDK2ALDH1A1 | |
| SCHEMBL2562056 | 0.81 | NTRK1 (0.47) | JAK2JAK3NTRK1CDK2ALDH1A1 | |
| SCHEMBL14061993 | 0.80 | PIN1 (0.48) | JAK2JAK3NTRK1AURKBAURKA | |
| SCHEMBL14061996 | 0.80 | PIN1 (0.48) | JAK2JAK3NTRK1AURKBAURKA | |
| SCHEMBL3013727 | 0.79 | JAK2 (0.64) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3020094 | 0.77 | JAK2 (0.49) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3772070 | 0.77 | JAK2 (0.62) | JAK2JAK3NTRK1AURKBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155742-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B]PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008129255-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |