Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | MUSK | O15146 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 13/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | STAT5B | P51692 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3009495 | 1.00 | JAK3 (0.42) | JAK3NTRK1CDK2LCKRET | |
| SCHEMBL3024002 | 0.84 | JAK2 (0.39) | JAK3NTRK1CDK2RETFLT3 | |
| SCHEMBL3666467 | 0.84 | JAK2 (0.39) | JAK3NTRK1CDK2RETFLT3 | |
| SCHEMBL3008853 | 0.83 | NTRK1 (0.36) | NTRK1PRKCQKCNH2 | |
| SCHEMBL3670923 | 0.83 | NTRK1 (0.36) | NTRK1PRKCQKCNH2 | |
| SCHEMBL2562058 | 0.83 | NTRK1 (0.47) | JAK3NTRK1CDK2CCNE1JAK2 | |
| SCHEMBL2562056 | 0.83 | NTRK1 (0.47) | JAK3NTRK1CDK2CCNE1JAK2 | |
| SCHEMBL3019305 | 0.82 | MAPT (0.54) | JAK3NTRK1CDK2LCKRET | |
| SCHEMBL3670774 | 0.82 | MAPT (0.54) | JAK3NTRK1CDK2LCKRET | |
| SCHEMBL14062114 | 0.81 | PIN1 (0.48) | JAK3NTRK1CDK2LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155742-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B]PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008129255-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |