Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 16/20 | 0.60 |
| ▸ | GSK3B | P49841 | 8/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.60 |
| ▸ | PRKACA | P17612 | 7/20 | 0.60 |
| ▸ | CLK2 | P49760 | 6/20 | 0.60 |
| ▸ | GSK3A | P49840 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 6/20 | 0.60 |
| ▸ | CSNK1G2 | P78368 | 5/20 | 0.60 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.60 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.60 |
| ▸ | PRKX | P51817 | 5/20 | 0.60 |
| ▸ | JAK3 | P52333 | 5/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285222 | 0.87 | CDC7 (0.53) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL4294218 | 0.84 | CDC7 (0.65) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL27810081 | 0.81 | CDC7 (0.53) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL3672059 | 0.77 | ROCK2 (0.71) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL4297793 | 0.76 | CDC7 (0.53) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL3666734 | 0.75 | CDC7 (1.00) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL22716110 | 0.74 | GSK3B (0.37) | GSK3BCLK4ROCK2MAP4K4CLK2 | |
| SCHEMBL28787688 | 0.74 | DYRK3 (0.52) | GSK3BCLK4ROCK2CLK2GSK3A | |
| SCHEMBL3675451 | 0.73 | CDC7 (0.58) | CDC7GSK3BCLK4ROCK2MAP4K4 | |
| SCHEMBL27674541 | 0.72 | CDC7 (0.59) | CDC7GSK3BCLK4ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |