Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 16/20 | 0.53 |
| ▸ | GSK3B | P49841 | 10/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.53 |
| ▸ | PRKACA | P17612 | 9/20 | 0.53 |
| ▸ | CLK2 | P49760 | 8/20 | 0.53 |
| ▸ | GSK3A | P49840 | 8/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.53 |
| ▸ | CDK2 | P24941 | 8/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 7/20 | 0.53 |
| ▸ | PRKG1 | Q13976 | 7/20 | 0.53 |
| ▸ | SGK2 | Q9HBY8 | 7/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.53 |
| ▸ | PRKX | P51817 | 7/20 | 0.53 |
| ▸ | JAK3 | P52333 | 7/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297793 | 0.90 | CDC7 (0.53) | CDC7GSK3BCLK4ROCK2PRKACA | |
| SCHEMBL3666525 | 0.87 | CDC7 (0.60) | CDC7GSK3BCLK4ROCK2PRKACA | |
| SCHEMBL3675451 | 0.86 | CDC7 (0.58) | CDC7GSK3BCLK4ROCK2PRKACA | |
| SCHEMBL27810081 | 0.82 | CDC7 (0.53) | CDC7GSK3BCLK4ROCK2PRKACA | |
| SCHEMBL3667784 | 0.80 | ROCK2 (0.65) | CDC7GSK3BCLK4ROCK2PRKACA | |
| SCHEMBL3670860 | 0.78 | DYRK3 (0.49) | GSK3BCLK4ROCK2CLK2GSK3A | |
| SCHEMBL22715071 | 0.77 | MAP2K4 (0.48) | GSK3BCLK4ROCK2CLK2GSK3A | |
| SCHEMBL29439673 | 0.77 | MAP2K4 (0.48) | GSK3BCLK4ROCK2CLK2GSK3A | |
| SCHEMBL2662495 | 0.74 | MAP2K4 (0.45) | GSK3BCLK4ROCK2CLK2GSK3A | |
| SCHEMBL4294218 | 0.73 | CDC7 (0.65) | CDC7GSK3BCLK4ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-11-20 | — | — | US | disclosed |
| US-8648069-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | CDC7 8/4885GSK3B 1/4885CLK4 260/4885 |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | CDC7 8/4885GSK3B 1/4885CLK4 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.