Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ATF4 | P18848 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647657 | 0.90 | ACHE (0.59) | UTS2RACHEMAOBMAPTMAPK1 | |
| SCHEMBL649805 | 0.89 | UTS2R (0.49) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL649806 | 0.89 | UTS2R (0.49) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL647034 | 0.88 | UTS2R (0.53) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL647035 | 0.88 | UTS2R (0.53) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL650882 | 0.87 | MAOB (0.51) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL648203 | 0.84 | UTS2R (0.51) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL648204 | 0.84 | UTS2R (0.51) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL648180 | 0.84 | MAOA (0.50) | UTS2RACHEMAOBMAOAMAPT | |
| SCHEMBL648181 | 0.84 | MAOA (0.50) | UTS2RACHEMAOBMAOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |