Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338792 | 0.87 | CHRNA7 (0.43) | PDE4BKDM4EPOLBCHRNA7ALDH1A1 | |
| SCHEMBL3337190 | 0.76 | ROCK2 (0.37) | PDE4BPOLB | |
| SCHEMBL4977321 | 0.74 | SLC22A12 (0.41) | LMNASMN1; SMN2HTTNPSR1 | |
| SCHEMBL3342070 | 0.73 | GPBAR1 (0.36) | ALDH1A1S1PR4 | |
| SCHEMBL3337435 | 0.73 | HPGD (0.41) | PDE4BKDM4EPOLBALDH1A1GAA | |
| SCHEMBL3336975 | 0.72 | GAA (0.40) | KDM4EALDH1A1GAALMNAPOLQ | |
| SCHEMBL3336934 | 0.72 | HPGD (0.40) | PDE4BKDM4EPOLBALDH1A1GAA | |
| SCHEMBL3337195 | 0.72 | GPBAR1 (0.33) | ALDH1A1S1PR3S1PR5 | |
| SCHEMBL3336740 | 0.72 | GPBAR1 (0.32) | ALDH1A1 | |
| SCHEMBL3338976 | 0.71 | EZH2 (0.38) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155194-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008124610-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |