Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 4/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628520 | 0.71 | SYK (0.44) | SYKNNMTZAP70 | |
| SCHEMBL584137 | 0.71 | NNMT (0.43) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL12272538 | 0.69 | NNMT (0.46) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL3666941 | 0.68 | SYK (0.36) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL1628519 | 0.68 | PTK2 (0.42) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL12575429 | 0.66 | NNMT (0.45) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL14981458 | 0.64 | SYK (0.51) | SYKNNMTPARP1ZAP70 | |
| SCHEMBL14726086 | 0.64 | SYK (0.42) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL4569214 | 0.64 | NNMT (0.40) | SYKSIRT3TDP1NNMTPARP1 | |
| SCHEMBL30945485 | 0.64 | HSD11B1 (0.45) | SYKSIRT3TDP1NNMTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146779-A1 | SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008129380-A1 | SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2008-10-30 | — | — | WO | disclosed |