Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495323 | 0.80 | IDO1 (0.46) | IDO1HTTMAPTAPPPDE5A | |
| SCHEMBL5546038 | 0.77 | MEN1 (0.44) | IDO1HTTMAPTPDE5AKDM4E | |
| SCHEMBL10628437 | 0.77 | IDO1 (0.43) | IDO1HTTMAPTAPPPDE5A | |
| SCHEMBL22962412 | 0.76 | MAPT (0.39) | IDO1HTTMAPTSPHK2SPHK1 | |
| SCHEMBL20375410 | 0.76 | MAPT (0.39) | IDO1HTTMAPTSPHK2SPHK1 | |
| SCHEMBL10313820 | 0.75 | IDO1 (0.42) | IDO1HTTMAPTAPPPDE5A | |
| SCHEMBL11512622 | 0.74 | IDO1 (0.55) | IDO1HTTMAPTAPPPDE5A | |
| SCHEMBL6096883 | 0.72 | L3MBTL1 (0.40) | HTTMAPTTLR8KDM4ENPC1 | |
| SCHEMBL6096888 | 0.72 | L3MBTL1 (0.40) | HTTMAPTTLR8KDM4ENPC1 | |
| SCHEMBL28787674 | 0.72 | ALDH1A1 (0.45) | HTTMAPTKDM4ECA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170846-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | Intervet International BV (NL) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009005646-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2007123949-A2 | CANNABINOID RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-1819684-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006060461-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2006-06-08 | — | — | WO | disclosed |