Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28320224 | 0.79 | HTT (0.37) | HTT | |
| SCHEMBL24815913 | 0.79 | TNF (0.33) | HTT | |
| SCHEMBL27474353 | 0.79 | ALDH1A1 (0.34) | HTTCYP3A4 | |
| SCHEMBL27248775 | 0.75 | TSHR (0.39) | MAPK1 | |
| SCHEMBL27248807 | 0.75 | PDE3B (0.40) | — | |
| SCHEMBL27248563 | 0.75 | ALDH1A1 (0.37) | — | |
| SCHEMBL30013654 | 0.74 | PARP1 (0.44) | TDP1 | |
| SCHEMBL3337344 | 0.74 | PARP1 (0.44) | TDP1 | |
| SCHEMBL4167763 | 0.71 | KDM4E (0.35) | HTTCYP3A4MAPK1 | |
| SCHEMBL23577134 | 0.71 | TNKS (0.33) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102584721-B | Synthetic method of 2,4-dichloroquinazoline derivative | UNIV ZHEJIANG TECHNOLOGY | 2014-07-02 | — | — | CN | disclosed |
| CN-103534251-A | Novel compounds for organic electronic material and organic electroluminescent device using the same | ROHM & HAAS ELECT MAT | 2014-01-22 | — | — | CN | disclosed |
| CN-102584721-A | Synthetic method of 2,4-dichloroquinazoline derivative | UNIV ZHEJIANG TECHNOLOGY | 2012-07-18 | — | — | CN | disclosed |
| EP-2238119-A1 | QUINAZOLINES AND RELATED HETEROCYCLIC COMPOUNDS, AND THEIR THERAPEUTIC USE | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg (NL) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009083608-A1 | QUINAZOLINES AND RELATED HETEROCYCLIC COMPOUNDS, AND THEIR THERAPEUTIC USE | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2009-07-09 | — | — | WO | disclosed |
| CN-1044245-C | Tricyclic Dicarbonyl derivatives | HAFFMANN LA ROCHE AG F (DE) | 1999-07-21 | — | — | CN | disclosed |
| CN-1149295-A | Tricyclic Dicarbonyl derivatives | HOFFMANN LA ROCHE (CH) | 1997-05-07 | — | — | CN | disclosed |