Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25468128 | 0.80 | ACHE (0.53) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL30584855 | 0.79 | CHRM5 (0.58) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL12435217 | 0.79 | CHRM5 (0.58) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL24608966 | 0.79 | KCNH2 (0.40) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL478537 | 0.78 | CHRM5 (0.39) | KCNH2CHRM5SIGMAR1ACHEADRA2C | |
| SCHEMBL19853554 | 0.78 | CHRM5 (0.57) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL24495768 | 0.78 | ACHE (0.66) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL10070997 | 0.77 | CHRM5 (0.61) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL22953689 | 0.77 | CHRM5 (0.61) | KCNH2CHRM5CHRM2ADRA2ACHRM1 | |
| SCHEMBL12359083 | 0.77 | KCNH2 (0.45) | KCNH2CHRM5CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240458-A1 | ARYL SULFONAMIDES AS EFFECTIVE ANALGESICS | Boehringer Ingelheim International GmbH (DE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009098051-A1 | ARYL SULFONAMIDES AS EFFECTIVE ANALGESICS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-13 | — | — | WO | disclosed |