SCHEMBL366778

SCHEMBL366778

CCCC=CC(C)(N)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.43
CYP1A2 P05177 3/20 0.40
GMNN O75496 2/20 0.40
USP2 O75604 2/20 0.40
POLB P06746 2/20 0.40
CYP2C9 P11712 2/20 0.40
APEX1 P27695 2/20 0.40
RECQL P46063 2/20 0.40
BLM P54132 2/20 0.40
HSD17B10 Q99714 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
ACLY P53396 1/20 0.34
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
GGT1 P19440 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
THRB P10828 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL366777 1.00 CYP2C19 (0.43) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL23534464 1.00 CYP2C19 (0.43) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL599741 1.00 CYP2C19 (0.43) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL16401330 0.88 CYP2C19 (0.49) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL16401654 0.88 CYP2C19 (0.49) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL16401332 0.88 CYP2C19 (0.49) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL20680343 0.86 CYP1A2 (0.56) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL19357333 0.86 CYP1A2 (0.56) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL14322640 0.85 CYP1A2 (0.58) CYP2C19CYP1A2GMNNUSP2POLB
SCHEMBL600897 0.85 CYP1A2 (0.58) CYP2C19CYP1A2GMNNUSP2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4399220-A1 ANTIVIRAL STRUCTURALLY-STAPLED SARS-COV-2 PEPTIDE- CHOLESTEROL CONJUGATES AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2024-07-17 EP claimed
CN-118202043-A Peptides with multivalent action 英图库尔公司 2024-06-14 CN claimed
EP-3359180-B1 STABILIZED BCL9 PEPTIDES FOR TREATMENT OF ABERRANT WNT SIGNALING WNTRX PHARMACEUTICALS INC (US) 2024-05-15 EP claimed
US-20240124529-A1 ANTIVIRAL STRUCTURALLY-STABILIZED SARS-CoV-2 PEPTIDES AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. 2024-04-18 US claimed
US-11952432-B2 Cell-permeable stapled peptide modules for cellular delivery DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-04-09 US claimed
US-11945846-B2 Stapled intracellular-targeting antimicrobial peptides to treat infection DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-04-02 US claimed
US-20240016943-A1 SYNTHETIC DNA BINDING DOMAINS AND USES THEREOF THE UNIVERSITY OF CHICAGO (US) 2024-01-18 US claimed
US-11865181-B2 Peptidic materials that traffic efficiently to the cell cytosol and nucleus YALE UNIVERSITY 2024-01-09 US claimed
CN-117304295-A Stabilized BCL9 peptides for the treatment of aberrant Wnt signaling 北京佳诚生物医药科技开发有限公司 2023-12-29 CN claimed
US-20230405134-A1 NOVEL PROTAC CHIMERIC COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING, AMELIORATING, OR TREATING DISEASES THROUGH TARGET PROTEIN DEGRADATION POSTECH Research and Business Development Foundation (KR) 2023-12-21 US claimed
US-8940864-B2 Stabilized therapeutic small helical antiviral peptides NEW YORK BLOOD CENTER, INC. (US) 2015-01-27 US claimed
US-8937154-B2 Stabilized therapeutic small helical antiviral peptides NEW YORK BLOOD CENTER, INC. (US) 2015-01-20 US claimed
US-8933019-B2 Antiviral cell-penetrating peptides NEW YORK BLOOD CENTER, INC. (US) 2015-01-13 US claimed
WO-2014072916-A1 MIMETIC PEPTIDES LES HOPITAUX UNIVERSITAIRES DE GENEVE (CH) 2014-05-15 WO claimed
US-20130059776-A1 Antiviral Cell-Penetrating Peptides NEW YORK BLOOD CENTER 2013-03-07 US claimed
US-8324153-B2 Antiviral cell-penetrating peptides NEW YORK BLOOD CENTER, INC. (US) 2012-12-04 US claimed
US-20120165249-A1 Stabilized Therapeutic Small Helical Antiviral Peptides NEW YORK BLOOD CENTER, INC. 2012-06-28 US claimed
EP-2283033-A1 ANTIVIRAL CELL PENETRATING PEPTIDES New York Blood Center (US) 2011-02-16 EP claimed
US-20090281041-A1 ANTIVIRAL CELL-PENETRATING PEPTIDES NEW YORK BLOOD CENTER 2009-11-12 US claimed
WO-2009137532-A1 ANTIVIRAL CELL PENETRATING PEPTIDES NEW YORK BLOOD CENTER (US) 2009-11-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124529-A1 ANTIVIRAL STRUCTURALLY-STABILIZED SARS-CoV-2 PEPTIDES AND USES THEREOF ACE2, SARS1, ACE CYP2C19 4011/4885CYP1A2 4648/4885GMNN 2187/4885
US-20240016943-A1 SYNTHETIC DNA BINDING DOMAINS AND USES THEREOF CBFB, CNBP, BPTF CYP2C19 4837/4885CYP1A2 4719/4885GMNN 983/4885
US-20230405134-A1 NOVEL PROTAC CHIMERIC COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING, AMELIORATING, OR TREATING DISEASES THROUGH TARGET PROTEIN DEGRADATION SRC, PSME1, PSMB11 CYP2C19 4204/4885CYP1A2 4336/4885GMNN 3909/4885
US-20130059776-A1 Antiviral Cell-Penetrating Peptides ZC3HAV1, MAVS, HAVCR2 CYP2C19 4477/4885CYP1A2 4845/4885GMNN 1535/4885
US-11945846-B2 Stapled intracellular-targeting antimicrobial peptides to treat infection VIP, SPPL2B, HM13 CYP2C19 4707/4885CYP1A2 4876/4885GMNN 2115/4885
US-11952432-B2 Cell-permeable stapled peptide modules for cellular delivery TAP1, TAP2, HM13 CYP2C19 4852/4885CYP1A2 4885/4885GMNN 1079/4885
US-20120165249-A1 Stabilized Therapeutic Small Helical Antiviral Peptides ZC3HAV1, VIP, ZC3HAV1L CYP2C19 4716/4885CYP1A2 4867/4885GMNN 1121/4885
US-20090281041-A1 ANTIVIRAL CELL-PENETRATING PEPTIDES ZC3HAV1, MAVS, HAVCR2 CYP2C19 4477/4885CYP1A2 4845/4885GMNN 1535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.