Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL20994210 | 1.00 | LMNA (0.37) | LMNABBOX1TSHRALDH1A1MAPK1 | |
| Oxalic Acid SCHEMBL23277203 | 0.91 | TSHR (0.38) | LMNABBOX1TSHRALDH1A1MAPK1 | |
| Hydrogen Peroxide SCHEMBL2240272 | 0.90 | TSHR (0.38) | BBOX1TSHRACHE | |
| Bicarbonate SCHEMBL366841 | 0.88 | BBOX1 (0.42) | LMNABBOX1TSHRALDH1A1MAPK1 | |
| Acetic Acid SCHEMBL27551468 | 0.88 | FFAR3 (0.39) | LMNABBOX1TSHRALDH1A1MAPK1 | |
| Bicarbonate SCHEMBL366839 | 0.85 | BBOX1 (0.43) | BBOX1TSHRALDH1A1MAPK1TDP1 | |
| Glycine SCHEMBL27647221 | 0.84 | GLRA1 (0.50) | LMNABBOX1TSHRALDH1A1ABCC4 | |
| SCHEMBL197824 | 0.83 | TSHR (0.33) | TSHRALDH1A1 | |
| Hydrogen Sulfide SCHEMBL28090943 | 0.83 | TSHR (0.33) | TSHRALDH1A1 | |
| Bicarbonate SCHEMBL10803061 | 0.82 | BBOX1 (0.42) | BBOX1TSHRALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 772 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183181-A1 | PROCESS OF PREPARING BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHENYL]ETHYL}[2-(2-{[3-CHLORO-4'-(TRIFLUOROMETHYL)[BIPHENYL]-4-YL]METHOXY}PHENYL)ETHYL]AMINO)-5,6,7,8-TETRAHYDROQUINOLINE-2-CARBOXYLATE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2023-06-15 | — | — | US | claimed |
| EP-4153569-A1 | PROCESS OF PREPARING BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHENYL]ETHYL}[2-(2-{[3-CHLORO-4'-(TRIFLUOROMETHYL)[BIPHENYL]-4-YL]METHOXY}PHENYL)ETHYL]AMINO)-5,6,7,8-TETRAHYDROQUINOLINE-2-CARBOXYLATE | Bayer Aktiengesellschaft (DE) | 2023-03-29 | — | — | EP | claimed |
| CN-114497813-B | Phase change composite film, and battery and chip assembly including the same | 深圳市森若新材科技有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-114497813-A | Phase change composite film, and battery and chip assembly including the same | 深圳市森若新材科技有限公司 | 2022-05-13 | — | — | CN | claimed |
| WO-2021234597-A1 | METHODS FOR PRODUCING ELECTRICAL ENERGY FROM REDUCED GRAPHENE OXIDE USING AMBIENT ENERGY, CELLS AND SYSTEMS THEREOF | TATA STEEL LIMITED (IN) | 2021-11-25 | — | — | WO | claimed |
| US-20190010281-A1 | METHOD FOR PRODUCING POLYCARBONATE OLIGOMERS | SHELL OIL COMPANY | 2019-01-10 | — | — | US | claimed |
| US-20180371163-A1 | METHOD FOR PRODUCING OLIGOMERS FOR PRODUCING POLYCARBONATES | SHELL OIL COMPANY | 2018-12-27 | — | — | US | claimed |
| EP-3394147-A1 | METHOD FOR PRODUCING OLIGOMERS FOR PRODUCING POLYCARBONATES | SHELL INTERNATIONAL RESEARCH MAATSCHAPPIJ B.V. (NL) | 2018-10-31 | — | — | EP | claimed |
| EP-3394148-A1 | METHOD FOR PRODUCING POLYCARBONATE OLIGOMERS | SHELL INTERNATIONAL RESEARCH MAATSCHAPPIJ B.V. (NL) | 2018-10-31 | — | — | EP | claimed |
| US-10022462-B2 | Methods and apparatus for synthesizing imaging agents, and intermediates thereof | LANTHEUS MEDICAL IMAGING, INC. (US) | 2018-07-17 | — | — | US | claimed |
| US-20030040595-A2 | POLYMER PREPARATION | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 2003-02-27 | — | — | US | claimed |
| US-20020095017-A1 | Polymer preparation | TOWNS ROBERT CARL (GB) | 2002-07-18 | — | — | US | claimed |
| US-6353072-B1 | Polymer preparation from boron derivative functional group-containing monomers | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 2002-03-05 | — | — | US | claimed |
| EP-1165648-A1 | POLYMER PREPARATION | Cambridge Display Technology Limited (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000053656-A1 | POLYMER PREPARATION | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 2000-09-14 | — | — | WO | claimed |
| WO-1999064434-A1 | SYNTHETIC METHODS AND INTERMEDIATES FOR TRIESTER OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | claimed |
| US-5169942-A | Using a quaternary phase-transfer agent, deacylation, fluorination | GENERAL ELECTRIC COMPANY (US) | 1992-12-08 | — | — | US | claimed |
| US-5023067-A | Aqueous slurry consisting of homogeneous dispersion of coprecipitated metal carbonates and quaternary ammonium salts | W. R. GRACE & CO.-CONN. (US) | 1991-06-11 | — | — | US | claimed |
| CN-1040572-A | The preparation method and the goods thereof of pottery | GRACE W R & CO (US) | 1990-03-21 | — | — | CN | claimed |
| EP-0355252-A2 | Manufacturing method for ceramics and products thereof | W.R. Grace & Co.-Conn. (US) | 1990-02-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10022462-B2 | Methods and apparatus for synthesizing imaging agents, and intermediates thereof | TNNI3, FABP3, MPI | LMNA 3154/4885BBOX1 3021/4885TSHR 2720/4885 |
| US-20230183181-A1 | PROCESS OF PREPARING BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHENYL]ETHYL}[2-(2-{[3-CHLORO-4'-(TRIFLUOROMETHYL)[BIPHENYL]-4-YL]METHOXY}PHENYL)ETHYL]AMINO)-5,6,7,8-TETRAHYDROQUINOLINE-2-CARBOXYLATE | CYP3A5, CYP4B1, KDM5B | LMNA 1233/4885BBOX1 63/4885TSHR 3532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.