SCHEMBL3668580

SCHEMBL3668580

[CH2]CCNS(=O)(=O)CCC

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.39
RELA Q04206 4/20 0.37
KDM4E B2RXH2 5/20 0.36
HSD17B10 Q99714 4/20 0.36
TP53 P04637 2/20 0.36
CA2 P00918 2/20 0.36
CA12 O43570 1/20 0.36
CA7 P43166 1/20 0.36
CA14 Q9ULX7 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HTT P42858 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAPK1 P28482 1/20 0.33
PPARA Q07869 2/20 0.31
TBXAS1 P24557 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2048673 0.86 CA1 (0.43) CA1RELAKDM4EHSD17B10TP53
SCHEMBL3665147 0.86 RELA (0.46) CA1RELAKDM4EHSD17B10TP53
SCHEMBL1050009 0.82
SCHEMBL1155970 0.82 CA1 (0.57) CA1RELAKDM4EHSD17B10TP53
SCHEMBL3665831 0.80
SCHEMBL7042054 0.78 RELA (0.55) CA1RELACA2CA12CA7
SCHEMBL7039396 0.78 RELA (0.55) CA1RELACA2CA12CA7
SCHEMBL7109328 0.78 RELA (0.55) CA1RELACA2CA12CA7
SCHEMBL5689484 0.78 CA1 (0.61) CA1RELACA2CA12CA7
SCHEMBL4813487 0.77 CA1 (0.46) CA1RELACA2CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7135487-B2 such as N-2-(4-Bromophenyl)propyl methanesulfonamide; sulfonamidation of the amine; glutamate receptor potentiators ELI LILLY AND COMPANY (US) 2006-11-14 US claimed
US-20060030599-A1 SULPHONAMIDE DERIVATIVES ARNOLD MACKLIN B 2006-02-09 US claimed
US-8754010-B2 Herbicidal mixtures BASF AKTIENGESELLSCHAFT (DE) 2014-06-17 US disclosed
US-20120302441-A1 HERBICIDAL MIXTURES BASF AKTIENGESELLSCHAFT (DE) 2012-11-29 US disclosed
EP-2215909-A2 HERBICIDAL MIXTURES BASF SE (DE) 2010-08-11 EP disclosed
US-20060276341-A1 Herbicidal mixtures BASF AKTIENGESELLSCHAFT (DE) 2006-12-07 US disclosed
EP-1608222-A2 HERBICIDAL MIXTURES BASF AKTIENGESELLSCHAFT (DE) 2005-12-28 EP disclosed
WO-2004080182-A2 HERBICIDAL MIXTURES BASF AKTIENGESELLSCHAFT (DE) 2004-09-23 WO disclosed
EP-0558076-B1 Silver halide photographic material FUJI PHOTO FILM CO LTD (JP) 1999-05-06 EP disclosed
EP-0528435-B1 Silver halide photographic material FUJI PHOTO FILM CO LTD (JP) 1997-05-21 EP disclosed
US-5393648-A Dispersion of hydrophobic compound dye and polymer; dye is inactuve during storage, but readily decolored and eluted i in processing FUJI PHOTO FILM CO., LTD. (JP) 1995-02-28 US disclosed
US-5391470-A Dispersion of hydrophobic compound and water-insoluble, organic solvent-soluble polymer FUJI PHOTO FILM CO., LTD. (JP) 1995-02-21 US disclosed
US-5288600-A Containing water insoluble, solvent solubility polymer FUJI PHOTO FILM CO., LTD. (JP) 1994-02-22 US disclosed
EP-0583004-A1 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1994-02-16 EP disclosed
US-5264333-A Multilayer element with emulsion FUJI PHOTO FILM CO., LTD. (JP) 1993-11-23 US disclosed
EP-0566063-A1 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1993-10-20 EP disclosed
EP-0528435-A1 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1993-02-24 EP disclosed
US-3944612-A HAIR DYE INTERMEDIATES CLAIROL INCORPORATED (US) 1976-03-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060030599-A1 SULPHONAMIDE DERIVATIVES GRIN2C, GLRA2, GLRA1 CA1 1993/4885RELA 3420/4885KDM4E 803/4885
US-20120302441-A1 HERBICIDAL MIXTURES RYR2, DDT, P2RX6 CA1 1241/4885RELA 4863/4885KDM4E 4463/4885
US-20060276341-A1 Herbicidal mixtures RYR2, DDT, P2RX6 CA1 1324/4885RELA 4869/4885KDM4E 4441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.