Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.40 |
| ▸ | RXRB | P28702 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011937 | 0.94 | RXRA (0.35) | RXRARXRBNR1H2NR1H3MIF | |
| SCHEMBL3730602 | 0.92 | RXRA (0.35) | RXRARXRBNR1H2NR1H3MIF | |
| SCHEMBL31622456 | 0.90 | RXRA (0.41) | RXRARXRBPDE3BPDE3ARXRG | |
| SCHEMBL14722603 | 0.90 | MIF (0.32) | RXRARXRBPDE3BPDE3AMIF | |
| SCHEMBL14722605 | 0.90 | MIF (0.32) | RXRARXRBPDE3BPDE3AMIF | |
| SCHEMBL14721680 | 0.89 | MIF (0.33) | RXRARXRBPDE3BPDE3AMIF | |
| SCHEMBL14721679 | 0.89 | MIF (0.33) | RXRARXRBPDE3BPDE3AMIF | |
| SCHEMBL1358620 | 0.89 | KDM4E (0.33) | MIFTP53MAPTALOX15HSD17B10 | |
| SCHEMBL12522431 | 0.88 | MIF (0.31) | PDE3BPDE3AMIFTP53MAPT | |
| SCHEMBL30855392 | 0.87 | RXRB (0.55) | RXRARXRBPDE3BPDE3ARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140080877-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, LLC (US) | 2014-03-20 | — | — | US | disclosed |
| US-8623896-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION, LLC (US) | 2014-01-07 | — | — | US | disclosed |
| EP-2592079-A2 | Insecticidal compounds | Syngenta Participations AG. (CH) | 2013-05-15 | — | — | EP | disclosed |
| EP-2518068-A2 | Insecticidal compounds | Syngenta Participations AG. (CH) | 2012-10-31 | — | — | EP | disclosed |
| EP-2238132-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| US-20100279999-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2238132-A2 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009080250-A2 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279999-A1 | INSECTICIDAL COMPOUNDS | CHRM1, ACHE, CHRM2 | RXRA 3246/4885RXRB 3764/4885PDE3B 92/4885 |
| US-20140080877-A1 | INSECTICIDAL COMPOUNDS | CHRM1, ACHE, CHRM2 | RXRA 3283/4885RXRB 3766/4885PDE3B 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.