Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.74 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.67 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 11/20 | 0.65 |
| ▸ | NPC1 | O15118 | 10/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | DDX3X | O00571 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674728 | 0.86 | DGAT1 (0.77) | DGAT1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3671390 | 0.86 | CSNK2A2 (0.65) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL604092 | 0.85 | DGAT1 (1.00) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL3670069 | 0.85 | DGAT1 (0.72) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL17318637 | 0.81 | CSNK2A2 (0.81) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL17318701 | 0.80 | CSNK2A2 (0.80) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL28791190 | 0.80 | CSNK2A2 (0.80) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL18762167 | 0.80 | CSNK2A2 (0.80) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL28791192 | 0.80 | CSNK2A2 (0.80) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 | |
| SCHEMBL3672702 | 0.79 | DGAT1 (0.59) | DGAT1CSNK2A2CSNK2A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | claimed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | claimed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |