Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 3/20 | 0.64 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605030 | 0.91 | CXCR1 (0.62) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5594945 | 0.89 | KMT2A (0.65) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595104 | 0.87 | CXCR1 (0.80) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL3678982 | 0.85 | MEN1 (0.67) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL1462371 | 0.83 | P2RX1 (0.68) | CXCR1CXCR2KMT2AMEN1MAPT | |
| SCHEMBL28457684 | 0.83 | KMT2A (0.83) | KMT2AMEN1TDP1MAPTHTT | |
| SCHEMBL3706835 | 0.82 | KMT2A (0.74) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6820181 | 0.82 | KMT2A (0.59) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL4925782 | 0.82 | CXCR1 (0.61) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595106 | 0.81 | KMT2A (0.69) | CXCR1CXCR2KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2010-09-16 | — | — | US | claimed |
| US-20070142450-A1 | Novel urea derivatives and their medical use | NEUROSEARCH A/S (DK) | 2007-06-21 | — | — | US | claimed |
| EP-2255848-A2 | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer | NeuroSearch AS (DK) | 2010-12-01 | — | — | EP | disclosed |
| US-20070142450-A1 | Novel urea derivatives and their medical use | NEUROSEARCH A/S (DK) | 2007-06-21 | — | — | US | disclosed |
| US-20070142450-A1 | Novel urea derivatives and their medical use | NEUROSEARCH A/S (DK) | 2007-06-21 | — | — | US | disclosed |
| US-20070142450-A1 | Novel urea derivatives and their medical use | NEUROSEARCH A/S (DK) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | CHRNA10, CHRNA4, CHRNA5 | CXCR1 3154/4885CXCR2 3271/4885KMT2A 716/4885 |
| US-20070142450-A1 | Novel urea derivatives and their medical use | ACHE, NMUR1, NMUR2 | CXCR1 1314/4885CXCR2 1517/4885KMT2A 2607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.