Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | DDX3X | O00571 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.68 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.67 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431552 | 0.85 | GRIK1 (0.73) | P2RX1MEN1KMT2AMAPTDDX3X | |
| SCHEMBL22092648 | 0.85 | MAPT (0.82) | P2RX1MEN1KMT2AMAPTDDX3X | |
| SCHEMBL29494959 | 0.85 | MAPT (0.82) | P2RX1MEN1KMT2AMAPTDDX3X | |
| SCHEMBL22092548 | 0.84 | CNR1 (0.85) | P2RX1MEN1KMT2AMAPTDDX3X | |
| SCHEMBL29494979 | 0.84 | CNR1 (0.85) | P2RX1MEN1KMT2AMAPTDDX3X | |
| SCHEMBL8370683 | 0.83 | MEN1 (0.83) | MEN1KMT2AMAPTDDX3XHTT | |
| SCHEMBL3668843 | 0.83 | CXCR1 (0.64) | MEN1KMT2AMAPTHTTCTDSP1 | |
| SCHEMBL1047211 | 0.82 | MEN1 (1.00) | MEN1KMT2AMAPTDDX3XHTT | |
| SCHEMBL1463506 | 0.81 | GRIK1 (0.73) | MEN1KMT2AMAPTHTTCNR1 | |
| SCHEMBL13812567 | 0.81 | P2RX1 (1.00) | P2RX1MEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663192-B1 | hERG1 CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | NEUROSEARCH AS (DK) | 2008-12-03 | — | — | EP | claimed |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | claimed |
| US-20060281794-A1 | Erg channel openers for the treatment of cardiac arrhythmias | NEUROSEARCH A/S (DK) | 2006-12-14 | — | — | US | claimed |
| CN-1845726-A | Erg channel openers for the treatment of cardiac arrhythmias | POSEIDON PHARMACEUTICALS AS (DK) | 2006-10-11 | — | — | CN | claimed |
| EP-1663192-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | Poseidon Pharmaceuticals A/S (DK) | 2006-06-07 | — | — | EP | claimed |
| WO-2005023237-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-03-17 | — | — | WO | claimed |
| WO-2005023238-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF HYPEREXCITABILITY-RELATED NEURONAL DISEASES | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-03-17 | — | — | WO | claimed |
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | claimed |
| EP-0693053-B1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 1999-01-20 | — | — | EP | claimed |
| US-5696138-A | Urea derivatives and their use | NEUROSEARCH A/S (DK) | 1997-12-09 | — | — | US | claimed |
| EP-0693053-A1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 1996-01-24 | — | — | EP | claimed |
| WO-1994022807-A1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 1994-10-13 | — | — | WO | claimed |
| US-20110071164-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | OLESEN SOEREN PETER | 2011-03-24 | — | — | US | disclosed |
| US-7851492-B2 | ERG channel openers for the treatment of cardiac arrhythmias | NEUROSEARCH A/S (DK) | 2010-12-14 | — | — | US | disclosed |
| EP-1663192-B1 | hERG1 CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | NEUROSEARCH AS (DK) | 2008-12-03 | — | — | EP | disclosed |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | disclosed |
| EP-0693053-B1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 1999-01-20 | — | — | EP | disclosed |
| US-5696138-A | Urea derivatives and their use | NEUROSEARCH A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| EP-0693053-A1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994022807-A1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 1994-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281794-A1 | Erg channel openers for the treatment of cardiac arrhythmias | KCNJ2, KCNN3, KCNE1 | P2RX1 572/4885MEN1 2084/4885KMT2A 2189/4885 |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | KCNJ2, KCNH2, KCNH3 | P2RX1 146/4885MEN1 3855/4885KMT2A 603/4885 |
| US-20110071164-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | KCNJ2, KCNN3, KCNE1 | P2RX1 572/4885MEN1 2084/4885KMT2A 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.