Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246906 | 0.76 | JAK2 (0.48) | JAK2JAK3KCNH2 | |
| SCHEMBL3668859 | 0.74 | PRSS1 (0.32) | — | |
| SCHEMBL1430800 | 0.72 | JAK2 (0.47) | JAK2JAK3KCNH2 | |
| SCHEMBL30434370 | 0.71 | DGAT1 (0.36) | JAK2JAK3KCNH2 | |
| SCHEMBL1581282 | 0.66 | JAK2 (0.58) | JAK2JAK3KCNH2 | |
| SCHEMBL30125238 | 0.66 | IKBKB (0.51) | JAK2PIM1PIM3 | |
| SCHEMBL1246898 | 0.66 | PIM1 (0.39) | JAK2JAK3KCNH2PIM1PIM3 | |
| SCHEMBL1893552 | 0.66 | JAK2 (0.59) | JAK2JAK3KCNH2 | |
| SCHEMBL30097121 | 0.65 | PIM1 (0.47) | JAK2JAK3KCNH2PIM1PIM3 | |
| SCHEMBL15608628 | 0.65 | PIM1 (0.45) | PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |
| EP-2299816-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2013-11-13 | — | — | EP | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009155156-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |