Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1428013 | 0.78 | IKBKB (0.43) | — | |
| SCHEMBL3668858 | 0.74 | JAK2 (0.38) | — | |
| SCHEMBL13621105 | 0.72 | DAO (0.47) | PRSS1TMPRSS15 | |
| SCHEMBL1579873 | 0.68 | JAK2 (0.42) | — | |
| SCHEMBL21956735 | 0.66 | FABP3 (0.36) | — | |
| SCHEMBL3671648 | 0.65 | IKBKB (0.43) | — | |
| SCHEMBL30125238 | 0.63 | IKBKB (0.51) | — | |
| SCHEMBL1249626 | 0.62 | PIK3CD (0.32) | — | |
| SCHEMBL21957026 | 0.62 | BDKRB1 (0.38) | DPP4 | |
| SCHEMBL24956333 | 0.62 | RAB9A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |