Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059849 | 0.94 | REV1 (0.74) | REV1SIGMAR1TMEM97CHRNA7CHRM2 | |
| SCHEMBL3165278 | 0.91 | REV1 (0.73) | REV1SIGMAR1TMEM97CHRNA7ABCB1 | |
| SCHEMBL3048990 | 0.91 | REV1 (0.77) | REV1SIGMAR1TMEM97CHRNA7ABCB1 | |
| SCHEMBL3055739 | 0.88 | REV1 (0.72) | REV1SIGMAR1TMEM97CHRNA7CHRM2 | |
| SCHEMBL3055433 | 0.87 | REV1 (0.70) | REV1SIGMAR1TMEM97CHRNA7CHRM2 | |
| SCHEMBL3046464 | 0.86 | REV1 (0.64) | REV1SIGMAR1TMEM97CHRNA7ABCB1 | |
| SCHEMBL3052241 | 0.86 | REV1 (0.76) | REV1SIGMAR1TMEM97CHRNA7CHRM2 | |
| SCHEMBL3059029 | 0.85 | REV1 (0.62) | REV1SIGMAR1TMEM97CHRNA7ABCB1 | |
| SCHEMBL3045901 | 0.85 | REV1 (0.68) | REV1SIGMAR1TMEM97CHRNA7CHRM2 | |
| SCHEMBL3050371 | 0.84 | REV1 (0.84) | REV1CHRNA7ABCB1KMT2AABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |