Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.76 |
| ▸ | ADCY1 | Q08828 | 12/20 | 0.52 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602153 | 0.86 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL600566 | 0.82 | DGAT1 (0.71) | DGAT1ADCY1ADCY8KDM4ELMNA | |
| SCHEMBL3673362 | 0.78 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL601174 | 0.77 | DGAT1 (0.84) | DGAT1 | |
| SCHEMBL3671390 | 0.72 | CSNK2A2 (0.65) | DGAT1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL22668537 | 0.69 | DGAT1 (0.52) | DGAT1ADCY1ADCY8KDM4ELMNA | |
| SCHEMBL20598174 | 0.69 | ADCY1 (1.00) | ADCY1ADCY8KDM4ELMNAMAPT | |
| SCHEMBL3665909 | 0.67 | RXFP1 (0.66) | DGAT1 | |
| SCHEMBL3674889 | 0.67 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL3670116 | 0.67 | DGAT1 (0.77) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | claimed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | claimed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |