Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 8/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28079678 | 0.88 | PTGS1 (0.53) | PTGS1MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL1416702 | 0.86 | PTGS1 (0.73) | PTGS1PTGS2MAPTSLC22A6CXCR1 | |
| SCHEMBL11155861 | 0.85 | PTGS1 (0.50) | PTGS1MAPTSMN1; SMN2LMNAAKR1C3 | |
| SCHEMBL1759907 | 0.84 | PTGS1 (0.65) | PTGS1PTGS2MAPTSLC22A6CXCR1 | |
| Hydrochloric Acid SCHEMBL11169237 | 0.84 | PTGS1 (0.49) | PTGS1MAPTSMN1; SMN2LMNAAKR1C3 | |
| SCHEMBL29537690 | 0.84 | PTGS1 (0.65) | PTGS1PTGS2MAPTSLC22A6CXCR1 | |
| SCHEMBL1991313 | 0.84 | PTGS1 (0.65) | PTGS1PTGS2MAPTSLC22A6CXCR1 | |
| SCHEMBL361183 | 0.83 | PTGS1 (0.73) | PTGS1PTGS2MAPTSLC22A6CXCR1 | |
| SCHEMBL15641441 | 0.83 | PTGS1 (0.73) | PTGS1PTGS2MAPTSLC22A6CXCR1 | |
| SCHEMBL31635557 | 0.83 | PTGS1 (0.73) | PTGS1PTGS2MAPTSLC22A6CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | BIEDIGER RONALD J | 2006-12-07 | — | — | US | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | VCAM1, ICAM1, ITGA1 | PTGS1 1253/4885PTGS2 3523/4885MAPT 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.