Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 7/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.45 |
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CLPP | Q16740 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622736 | 0.84 | SPR (0.46) | HTR2CTNKSTNKS2PARP1PARP2 | |
| SCHEMBL1622887 | 0.82 | CLPP (0.61) | HTR2CCLPPLMNAKDM4EPKM | |
| SCHEMBL1622562 | 0.77 | HTR2C (0.59) | HTR2CTNKS2HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1623598 | 0.76 | HTR2C (0.58) | HTR2CTNKSTNKS2PARP1PARP2 | |
| SCHEMBL3669615 | 0.75 | HTR2C (0.49) | HTR2CKDM4EALDH1A1 | |
| SCHEMBL1622628 | 0.75 | HTR2C (0.56) | HTR2CTNKS2PARP1PARP2 | |
| SCHEMBL7776836 | 0.75 | PARP1 (0.53) | HTR2CTNKSTNKS2PARP1PARP2 | |
| SCHEMBL3669798 | 0.74 | HTR2C (0.50) | HTR2CLMNAKDM4EHTTALDH1A1 | |
| SCHEMBL1622868 | 0.73 | HTR2C (0.67) | HTR2CCLPP | |
| SCHEMBL1623273 | 0.71 | CLPP (0.60) | HTR2CMAPTCLPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139896-A1 | PYRIMIDO [4, 5-D]AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | Pfizer Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008117169-A1 | PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | PFIZER LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |