Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2918046 | 0.82 | GRIA1 (0.56) | GRIA1GRIA3PDE4D | |
| Water SCHEMBL4777578 | 0.82 | GRIA1 (0.56) | GRIA1GRIA3PDE4D | |
| SCHEMBL2925898 | 0.74 | GRIA1 (0.50) | GRIA1GRIA3PDE4DFFAR1 | |
| SCHEMBL1885896 | 0.73 | GRIA1 (0.68) | GRIA1GRIA3PDE4DADORA2A | |
| SCHEMBL4463772 | 0.73 | GRIA1 (0.50) | GRIA1GRIA3PDE4D | |
| SCHEMBL3475505 | 0.72 | GRIA1 (0.52) | GRIA1GRIA3PDE4DADORA2A | |
| SCHEMBL18411434 | 0.72 | GRIA1 (0.53) | GRIA1GRIA3PDE4DCYP19A1 | |
| SCHEMBL5046202 | 0.71 | GRIA1 (0.48) | GRIA1GRIA3PDE4D | |
| SCHEMBL18411316 | 0.71 | GRIA1 (0.52) | GRIA1GRIA3PDE4DCYP19A1 | |
| SCHEMBL2762971 | 0.71 | GRIA1 (0.46) | GRIA1GRIA3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164487-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009011411-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |