Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.35 |
| ▸ | ACACA | Q13085 | 4/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29960795 | 0.73 | DRD2 (0.45) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL31554107 | 0.67 | ACACB (0.37) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL29875921 | 0.67 | GAA (0.42) | GAAALDH1A1HPGD | |
| SCHEMBL30782840 | 0.66 | DRD2 (0.36) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL29959933 | 0.65 | DRD2 (0.46) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL24756661 | 0.65 | MAPKAPK2 (0.44) | MAPKAPK2NAMPTCA1CA2CA9 | |
| SCHEMBL13213536 | 0.63 | NFKB1 (0.36) | CKS1BSKP1SKP2MAPKAPK2GAA | |
| SCHEMBL31431106 | 0.62 | CACNA1H (0.47) | MAPKAPK2AAK1NAMPT | |
| SCHEMBL2750096 | 0.62 | HCRTR2 (0.47) | DRD2GAACA1CA2CA7 | |
| SCHEMBL590406 | 0.62 | HCRTR2 (0.47) | DRD2GAACA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |