Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128108 | 0.84 | TGFBR1 (0.48) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2126398 | 0.78 | TGFBR1 (0.64) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2126260 | 0.75 | TGFBR1 (0.51) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2128085 | 0.74 | TGFBR1 (0.77) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2125422 | 0.71 | TGFBR1 (0.50) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2128905 | 0.71 | TGFBR1 (0.59) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2127268 | 0.70 | ALDH1A1 (0.41) | MEN1MAPTKMT2A | |
| SCHEMBL2128877 | 0.69 | TGFBR1 (0.54) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL27732302 | 0.69 | TGFBR1 (0.42) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL2127625 | 0.68 | MEN1 (0.38) | TGFBR1PRKD3PRKD1PRKD2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881834-B1 | PTERIDINES USEFUL AS HCV INHIBITORS AND METHODS FOR THE PREPARATION THEREOF | JANSSEN R & D IRELAND (IE) | 2012-04-25 | — | — | EP | disclosed |