Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670145 | 1.00 | TP53 (0.43) | TP53TSHRALDH1A1HDAC8HDAC6 | |
| SCHEMBL901209 | 0.87 | TSHR (0.57) | TP53TSHRALDH1A1HDAC8HDAC6 | |
| SCHEMBL2321634 | 0.87 | TSHR (0.57) | TP53TSHRALDH1A1HDAC8HDAC6 | |
| SCHEMBL901207 | 0.87 | TSHR (0.57) | TP53TSHRALDH1A1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL4290507 | 0.85 | TSHR (0.55) | TP53TSHRALDH1A1HDAC8HDAC6 | |
| SCHEMBL6853901 | 0.84 | HDAC2 (0.43) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL9258145 | 0.84 | CYP2C9 (0.56) | ALDH1A1HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL9258155 | 0.84 | CYP2C9 (0.56) | ALDH1A1HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL12212993 | 0.82 | ALDH1A1 (0.68) | TP53TSHRALDH1A1HDAC8HDAC6 | |
| SCHEMBL12212991 | 0.82 | ALDH1A1 (0.68) | TP53TSHRALDH1A1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-B1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-04-30 | — | — | EP | disclosed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |