SCHEMBL9258155

SCHEMBL9258155

NC(=O)c1ccc(C2CCC(C=O)CC2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.56
PARP10 Q53GL7 10/20 0.43
PARP15 Q460N3 5/20 0.42
PARP2 Q9UGN5 2/20 0.42
DGAT1 O75907 2/20 0.42
HDAC8 Q9BY41 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
ALDH1A1 P00352 2/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
PARP14 Q460N5 3/20 0.38
CCNA2 P20248 1/20 0.38
CDK2 P24941 1/20 0.38
CCNA1 P78396 1/20 0.38
PARP3 Q9Y6F1 1/20 0.38
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9258145 1.00 CYP2C9 (0.56) CYP2C9PARP10PARP15PARP2DGAT1
SCHEMBL2762400 0.87 CYP2C9 (0.69) CYP2C9PARP10PARP15PARP2DGAT1
Hydrochloric Acid SCHEMBL28200483 0.85 CYP2C9 (0.67) CYP2C9PARP10PARP15PARP2DGAT1
SCHEMBL3670145 0.84 TP53 (0.43) CYP2C9HDAC8HDAC6HDAC1HDAC2
SCHEMBL3670143 0.84 TP53 (0.43) CYP2C9HDAC8HDAC6HDAC1HDAC2
SCHEMBL6853901 0.83 HDAC2 (0.43) CYP2C9HDAC8HDAC6HDAC1HDAC2
SCHEMBL460922 0.81 CYP2C9 (0.51) CYP2C9PARP10PARP15PARP2DGAT1
SCHEMBL460921 0.81 CYP2C9 (0.51) CYP2C9PARP10PARP15PARP2DGAT1
SCHEMBL461355 0.81 CYP2C9 (0.51) CYP2C9PARP10PARP15PARP2DGAT1
SCHEMBL461356 0.81 CYP2C9 (0.51) CYP2C9PARP10PARP15PARP2DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5454974-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1995-10-03 US disclosed
US-5302317-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
US-5230826-A HALOBENZENE LIQUID CRYSTALS HOFFMANN-LA ROCHE INC. (US) 1993-07-27 US disclosed
US-5013477-A Alkenylbicyclohexane liquid crystals HOFFMANN-LA ROCHE INC. (US) 1991-05-07 US disclosed