Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668702 | 0.86 | RAF1 (0.31) | MAPT | |
| SCHEMBL16493948 | 0.82 | MAPT (0.31) | CSNK1DKDM4EPOLBMAPT | |
| Hydrochloric Acid SCHEMBL3665460 | 0.80 | MAPT (0.32) | KMT2ACSNK1DKDM4EMAPT | |
| SCHEMBL1205000 | 0.78 | CSNK1D (0.41) | KMT2ACSNK1DKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL16494128 | 0.77 | CSNK1D (0.32) | KMT2ACSNK1DGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL1205158 | 0.76 | NPC1 (0.37) | KMT2ACSNK1DMEN1ALDH1A1 | |
| SCHEMBL1205982 | 0.72 | KDM4E (0.39) | CSNK1DGAAKDM4EMAPTTHRB | |
| SCHEMBL10204128 | 0.68 | RXFP1 (0.38) | GAAKDM4EPOLBBLML3MBTL1 | |
| SCHEMBL1205097 | 0.68 | F2R (0.36) | CSNK1D | |
| SCHEMBL10204139 | 0.68 | ALDH1A1 (0.37) | KMT2AGAAKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240487-B1 | TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS | SANOFI SA (FR) | 2011-12-14 | — | — | EP | disclosed |
| EP-2240487-A1 | TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS | Sanofi-Aventis (FR) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009097970-A1 | TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS | SANOFI-AVENTIS (FR) | 2009-08-13 | — | — | WO | disclosed |