Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.53 |
| ▸ | L3MBTL3 | Q96JM7 | 9/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681359 | 0.97 | CHRNA7 (0.51) | L3MBTL1L3MBTL3CHRNA7HRH3MBTD1 | |
| SCHEMBL29965093 | 0.93 | HRH3 (0.52) | L3MBTL1L3MBTL3CHRNA7HRH3MBTD1 | |
| SCHEMBL2326470 | 0.90 | L3MBTL3 (0.62) | L3MBTL1L3MBTL3CHRNA7HRH3MBTD1 | |
| SCHEMBL6367051 | 0.88 | HRH3 (0.43) | L3MBTL1L3MBTL3CHRNA7HRH3ADRA2A | |
| SCHEMBL5225092 | 0.88 | HRH3 (0.43) | L3MBTL1L3MBTL3CHRNA7HRH3ADRA2A | |
| SCHEMBL6365166 | 0.88 | HRH3 (0.43) | L3MBTL1L3MBTL3CHRNA7HRH3ADRA2A | |
| SCHEMBL29104019 | 0.81 | L3MBTL3 (0.81) | L3MBTL1L3MBTL3MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL27800840 | 0.80 | HDAC4 (0.48) | L3MBTL1L3MBTL3MBTD1TP53BP1POLB | |
| SCHEMBL27800639 | 0.80 | HDAC4 (0.48) | L3MBTL1L3MBTL3MBTD1TP53BP1POLB | |
| SCHEMBL3666964 | 0.80 | HDAC4 (0.48) | L3MBTL1L3MBTL3MBTD1TP53BP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2237779-A1 | BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE | Abbott Laboratories (US) | 2010-10-13 | — | — | EP | claimed |
| WO-2009085945-A1 | BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | WO | claimed |