Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 11/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 7/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800840 | 1.00 | HDAC4 (0.48) | HDAC4L3MBTL3MBTD1L3MBTL1TP53 | |
| SCHEMBL27800639 | 1.00 | HDAC4 (0.48) | HDAC4L3MBTL3MBTD1L3MBTL1TP53 | |
| SCHEMBL27821597 | 0.96 | HDAC4 (0.49) | HDAC4L3MBTL3MBTD1L3MBTL1TP53 | |
| SCHEMBL28785960 | 0.96 | HDAC4 (0.49) | HDAC4L3MBTL3MBTD1L3MBTL1TP53 | |
| SCHEMBL27821598 | 0.96 | HDAC4 (0.49) | HDAC4L3MBTL3MBTD1L3MBTL1TP53 | |
| SCHEMBL3670183 | 0.80 | L3MBTL1 (0.53) | HDAC4L3MBTL3MBTD1L3MBTL1L3MBTL4 | |
| SCHEMBL2174158 | 0.79 | ALDH1A1 (0.50) | L3MBTL1 | |
| SCHEMBL265128 | 0.79 | ALDH1A1 (0.50) | L3MBTL1 | |
| SCHEMBL31334193 | 0.78 | SMARCA2 (0.40) | L3MBTL1 | |
| SCHEMBL31334501 | 0.78 | SMARCA2 (0.40) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101951904-A | Benzothiazole and benzoxazole derivatives and methods of use | ABBOTT LAB | 2011-01-19 | — | — | CN | claimed |
| CN-101951904-A | Benzothiazole and benzoxazole derivatives and methods of use | ABBOTT LAB | 2011-01-19 | — | — | CN | disclosed |
| EP-2237779-A1 | BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE | Abbott Laboratories (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009085945-A1 | BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | WO | disclosed |