Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 3/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668331 | 0.83 | TSHR (0.31) | KCNH2 | |
| SCHEMBL3025535 | 0.82 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL3020658 | 0.79 | TSHR (0.31) | KCNH2 | |
| SCHEMBL3666201 | 0.79 | TSHR (0.31) | KCNH2 | |
| SCHEMBL3016694 | 0.72 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL3016687 | 0.72 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL3669003 | 0.71 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL3013394 | 0.68 | KCNH2 (0.34) | KCNH2SYK | |
| SCHEMBL3149928 | 0.67 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL3025404 | 0.63 | KDM4C (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |