Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 8/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.42 |
| ▸ | IGF1R | P08069 | 7/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512971 | 0.90 | HTR6 (0.47) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL589358 | 0.85 | KDM4E (0.51) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL1334262 | 0.84 | INSR (0.47) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL18918322 | 0.83 | HTR6 (0.45) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL30957440 | 0.82 | ALK (0.50) | INSRALKIGF1RHTR6AURKA | |
| SCHEMBL589318 | 0.82 | ALK (0.50) | INSRALKIGF1RHTR6AURKA | |
| SCHEMBL3512534 | 0.82 | INSR (0.43) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL3513509 | 0.82 | HTR6 (0.43) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL3513050 | 0.82 | HTR6 (0.43) | INSRALKIGF1RHTR6MAPT | |
| SCHEMBL3513046 | 0.82 | HTR6 (0.43) | INSRALKIGF1RHTR6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |